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KMID : 1123920120260030281
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 3 p.281 ~ p.286
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Effect of Rehmannia glutinosa on Phosphorylation of ERK and CREB in Acute Cocaine-treated Rats
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Kwon Ki-Won
Jang Eun-Young
Im Chae-Kwang
Yang Chae-Ha
Kim Kwang-Joong
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Abstract
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The present study was designed to investigate the effect of Rehmannia glutinosa on phosphorylation of extracellular signal-regulated kinase(ERK) and cAMP response element-binding protein(CREB) in the acute cocaine-treated rats. Rats orally received vehicle or extract of Rehmannia glutinosa 1 h prior to saline (1 ml/kg, i.p.) or cocaine hydrochloride (20 mg/kg, i.p.) treatment. Rats were sacrificed 15 min after a single intraperitoneal injection of saline or cocaine. Rehmannia glutinosa at dose of 50 mg/kg significantly decreased phosphorylation of ERK, CREB and Elk-1 in the nucleus accumbens and striatum of the cocaine-treated rat brain by immunocytochemistry. These results suggest that Rehmannia glutinosa may contribute to the effects of cocaine on gene expression and on behaviors.
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KEYWORD
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Rehmannia glutinosa, acute cocaine, ERK, CREB, striatum, nucleus accumbens
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